{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:04:16Z","timestamp":1792415056458,"version":"4.4.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Objective:<\/i><\/b> To describe the clinical characteristics, biochemistry, histopathology, and long-term outcomes in subjects with ovotesticular (OT) disorder of sex development (DSD). <b><i>Study Design:<\/i><\/b> This is a retrospective subset analysis of 64 cases of histologically confirmed OT DSD. <b><i>Results:<\/i><\/b> All subjects were South African; 97% (<i>n<\/i> = 62) were African and 92% (<i>n<\/i> = 59) were of Zulu ethnicity. The most common karyotype was 46,XX (88%; <i>n<\/i> = 56), followed by 46,XY (8%), 46,XY\/45,X (3%), and 46,XX\/46,XY (1%). The median age at presentation was 7 months (0.5 months to 5.1 years). Sixty-one of the subjects (95%) presented with DSD. The ovotestis was the most frequent gonad (56%), followed by the ovary (23%) and the testis (16%). Testes were more commonly located on the right and ovaries on the left (<i>p<\/i> &#x3c; 0.0001). The male gender was the predominant sex of rearing in two-thirds of the subjects. Gender dysphoria was noted in 8 subjects (11%) at a median of 6.4 (4.3\u20139.3) years. Long-term follow-up (<i>n<\/i> = 14) revealed spontaneous puberty in 5 subjects, gender dysphoria in 2 subjects, and neuropsychiatric disorders in 4 subjects. <b><i>Conclusion:<\/i><\/b> OT DSD is an important differential diagnosis in Black South Africans with 46,XX DSD.<\/jats:p>","DOI":"10.1159\/000466693","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T21:01:31Z","timestamp":1492635691000},"page":"307-314","source":"Crossref","is-referenced-by-count":48,"title":["The Spectrum of Ovotesticular Disorders of Sex Development in South Africa: A Single-Centre Experience"],"prefix":"10.1159","volume":"87","author":[{"given":"Yasmeen","family":"Ganie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Aldous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusentha","family":"Balakrishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinus","family":"Wiersma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2350\/14-04-1466-PB.1"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.08.013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2016-0152"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s003830000415"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-004-1200-0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(94)70067-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050077"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.10.003"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2010.02700.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2013.10.037"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12857"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000362414"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200204000-00088"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01883323"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1985.tb07052.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2004.02.001"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1590\/S1677-55382008000500008"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2015-0032"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/466693","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/466693","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/466693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:16:55Z","timestamp":1745428615000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000466693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":18,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,7,4]]},"published-print":{"date-parts":[[2017,6,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000466693","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}