{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:53:15Z","timestamp":1761238395330,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; Retropharyngeal lesions are often associated with Kawasaki disease (KD). A 4-year-old male first presented a peritonsillar and retropharyngeal abscess-like lesion. Surgical tonsillectomy was performed to avoid a risk of mediastinal abscess, but he fulfilled the diagnostic criteria of KD after the operation. This prompted us to perform a histological study on the KD tonsils. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; The&lt;b&gt; &lt;\/b&gt;histopathology of the KD tonsil specimens were compared with hypertrophic tonsils obtained from 4 patients with chronic tonsillitis unrelated to KD assessed by the immunostainings. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; KD tonsils showed small lymphatic follicles and neutrophil infiltration in the peritonsillar muscle layer, with no evidence of vasculitis or abscess formation. The KD tonsils exclusively showed (1) predominant activated CD4&lt;sup&gt;+&lt;\/sup&gt; T cells in the perifollicular interstitium, (2) sparse scattering of CD68&lt;sup&gt;+&lt;\/sup&gt; monocytes\/macrophages in the lymphatic follicles, and (3) polyclonal carcinoembryonic antigen-positive cells in the lymphatic follicles and venules with the high endothelial cells. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The uniquely distributed immunocytes suggest the inflammatory process of KD involving the pathogen-associated molecules.<\/jats:p>","DOI":"10.1159\/000467388","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T21:01:40Z","timestamp":1493845300000},"page":"237-243","source":"Crossref","is-referenced-by-count":5,"title":["Distinct Distribution of Immunocytes in a Retropharyngeal Lymphadenopathy Associated with Kawasaki Disease: A Case Study Compared with Tonsillitis"],"prefix":"10.1159","volume":"137","author":[{"given":"Seigo","family":"Okada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Kobayashi-Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsunori","family":"Oga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Furuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Ikemoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironori","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasufumi","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunji","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kusuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouichi","family":"Ohga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-012-0734-z"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02821.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2013.878475"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2011.12.6.700"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1086\/323155"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/cei.12327"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/631787"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2179-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113054"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/nri3298"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71611"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.5.1469"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03135.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1086-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2014.07.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-0726"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000152901.06689.d4"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/467388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/467388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:17:05Z","timestamp":1745428625000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000467388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,7,11]]},"published-print":{"date-parts":[[2017,7,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000467388","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"type":"print","value":"0008-6312"},{"type":"electronic","value":"1421-9751"}],"subject":[],"published":{"date-parts":[[2017]]}}}