{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:12:18Z","timestamp":1776849138353,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement"],"abstract":"<jats:p>A patient with echinococcosis, acquired deficiency of the inhibitor of the activated\nfirst component of complement and angioedema symptoms has been studied. These\nsymptoms started 7 months after the surgical removal of an echinococcus liver cyst. Eight\nyears later, when the complement was investigated, a marked deficiency of the C1 inhibitor,\nCl, C4 and CH50 was present. The patient was therefore successfully treated with tranexamic\nacid. After 4 years, the woman needed another operation because of a relapse of echinococcosis;\nafterwards she was symptom-free without medications, while the complement profile\nremained unchanged. Circulating immune complexes were detected by the conglutinin method.\nThe patient\u2019s serum was demonstrated to possess an anticomplementary activity without\naffecting the Cl inhibitor when incubated with normal human serum at 37 \u00b0C. At present, 16\nyears after the onset of the symptoms, there are no signs of lymphoprolif\u00e9rative disease.<\/jats:p>","DOI":"10.1159\/000467853","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:18:59Z","timestamp":1502471939000},"page":"133-139","source":"Crossref","is-referenced-by-count":24,"title":["Acquired C1 Inhibitor Deficiency with Angioedema Symptoms\nin a Patient Infected with Echinococcus granulosus"],"prefix":"10.1159","author":[{"given":"M.","family":"Cicardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Frangi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Bergamaschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gardinali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Sacchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Agostoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Complement"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000467853","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:13:54Z","timestamp":1776845634000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000467853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000467853","archive":["Portico"],"relation":{},"ISSN":["0253-5076","2504-2424"],"issn-type":[{"value":"0253-5076","type":"print"},{"value":"2504-2424","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}