{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:12:31Z","timestamp":1776849151307,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement"],"abstract":"<jats:p>Certain complement inhibitors, namely chlorpromazine, suramin, 2-hydroxystilbamidine\nand chlorophenothiazine sulphonate were tested for their ability to suppress\ncomplement deposition and vascular injury at the site of an Arthus reaction. Deposition of\ncomplement was suppressed in the order 2-hydroxystilbamidine &gt; suramin &gt; chlorpromazine.\nAll the above mentioned four compounds strongly protected vascular injury as observed\nby electron microscopic studies. At Arthus reaction sites prepared without drug treatment\nvenules ranged from normal to severely altered and damaged. Discontinuities in endothelial\nlinings varied from small to longer stretches. In the latter situation remaining endothelial cells\nwere degenerated and endothelial remnants did not have an intact basal lamina. After treatment\nwith the above complement inhibitors, at arthus reaction sites some venules appeared\nnormal, whereas others were altered but in all cases the endothelium and its basal lamina\nremained intact.<\/jats:p>","DOI":"10.1159\/000467876","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:19:22Z","timestamp":1502471962000},"page":"40-48","source":"Crossref","is-referenced-by-count":5,"title":["Suppression of Complement-Mediated Vascular Injury at\nArthus Reaction Sites by Complement Inhibitors"],"prefix":"10.1159","author":[{"given":"S.S.","family":"Asghar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.P.","family":"Dingemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kammeijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.R.","family":"Faber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.Y.M.","family":"Abdel Mawla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Complement"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000467876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:14:09Z","timestamp":1776845649000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000467876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000467876","archive":["Portico"],"relation":{},"ISSN":["0253-5076","2504-2424"],"issn-type":[{"value":"0253-5076","type":"print"},{"value":"2504-2424","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}