{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T14:31:01Z","timestamp":1790865061248,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement"],"abstract":"<jats:p>Expression of the C3b\/C4b receptor (CR1) on erythrocytes is decreased in\npatients with systemic lupus erythematosus (SLE) compared to normal individuals, and the\nCR1 antigen is absent from podocytes in severe diffuse proliferate nephritis of SLE. In the\npresent study, we examined the relationship between the number of CR 1 on erythrocytes and\nthe occurrence and severity of SLE nephritis, and assessed the expression of CR1 on erythrocytes\nin non-SLE nephritis and other systemic inflammatory diseases by measuring the binding\nof 125I-labeled rabbit F(ab')2 and murine monoclonal IgG anti-CRl antibodies to erythrocytes\nof normal individuals and patients in a French population. The number of binding\nsites for monoclonal anti-CRl antibody on erythrocytes of 116 normal individuals was 743 \u00b1\n22 (mean \u00b1 SEM) with a range of 169-1,333, and the frequency distribution of this number in\nthe population was bimodal. In 112 patients with SLE, the mean number of CR1 sites on\nerythrocytes was decreased to 62% of the mean for normal individuals (p &lt; 0.001). No\ncorrelation was found between CR1 expression on erythrocytes and the presence or immunohistopathological\ntype of glomerulonephritis in biopsy specimens from these patients. The\nmean number of CR1 on erythrocytes of 29 patients with non-SLE glomerulonephritis was\nslightly decreased to 89% of the normal mean (p &gt; 0.05), which could not be attributed to\nglomerular immune complex disease or vasculitis. The expression of CR 1 on erythrocytes of\npatients having rheumatoid arthritis (37 patients), scleroderma (9 patients), Sjogren\u2019s syndrome\n(5 patients), mixed connective tissue disease (5 patients), and dermatopolymyositis\n(4 patients) was not decreased. These results emphasize the unique association of low numbers\nof CR 1 sites on erythrocytes with SLE, irrespectively of the expression of the disease in a\ncritical organ system.<\/jats:p>","DOI":"10.1159\/000467884","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:19:07Z","timestamp":1502471947000},"page":"88-96","source":"Crossref","is-referenced-by-count":13,"title":["Decreased Expression of C3b Receptor (CR1) on Erythrocytes\nof Patients with Systemic Lupus erythematosus Contrasts with\nIts Normal Expression in Other Systemic Diseases and Does\nNot Correlate with the Occurrence or Severity of SLE Nephritis"],"prefix":"10.1159","author":[{"given":"Marie-H\u00e9l\u00e8ne","family":"Jouvin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bourgeois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T.","family":"Fearon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel D.","family":"Kazatchkine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Complement"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000467884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:14:06Z","timestamp":1776845646000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000467884"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000467884","archive":["Portico"],"relation":{},"ISSN":["0253-5076","2504-2424"],"issn-type":[{"value":"0253-5076","type":"print"},{"value":"2504-2424","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}