{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:12:38Z","timestamp":1776849158917,"version":"3.51.2"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Complement"],"abstract":"<jats:p>Anaphylatoxins, in particular C3a and C5a, have various biological activities\nwhich suggest a role as mediators of inflammatory reactions: they cause contraction of smooth\nmuscle, histamine release, increase in capillary permeability, adhesion of leukocytes to vascular\nendothelium, leukocyte chemotaxis, and aggregation of platelets and leukocytes. Most of\nthese effects are supported by the cooperation of other mediators, in particular arachidonic\nacid derivatives which may be produced by anaphylatoxin-stimulated cells, e.g. leukocytes or\nendothelium. In vivo effects of the complement peptides depend very much on the site of\ntheir generation: intravascular release in the general circulation leads to adverse symptoms\nsuch as adult respiratory distress syndrome and shock lung, mainly due to leukocyte activation,\naggregation and their accumulation in lung vessels. Intravascular release may be induced\nby certain drugs, and by contact of blood with the surfaces of bypass or dialysis apparatus.\nInduction of local inflammatory and defense reactions requires release of anaphylatoxins in\ntissue spaces. Tissue fluid differs quantitatively from blood plasma in its concentration of\ncomplement components. This raises some problems of how efficient concentrations of C3a\nand C5a can be attained at the site of a lesion to generate a chemotactic gradient capable of\nattracting blood leukocytes.<\/jats:p>","DOI":"10.1159\/000467894","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:19:12Z","timestamp":1502471952000},"page":"177-188","source":"Crossref","is-referenced-by-count":88,"title":["Anaphylatoxins: Possible Roles in Disease"],"prefix":"10.1159","author":[{"given":"Walther","family":"Vogt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Complement"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000467894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T08:14:15Z","timestamp":1776845655000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000467894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000467894","archive":["Portico"],"relation":{},"ISSN":["0253-5076","2504-2424"],"issn-type":[{"value":"0253-5076","type":"print"},{"value":"2504-2424","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}