{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:25:47Z","timestamp":1791066347491,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Pharmacopsychiatry"],"abstract":"<jats:p>The significance of the alteration in circadian rhythm in endogenous depression\nis discussed.\n23 patients with endogenous depression, 11 patients with neurotic depression and 23\nhealthy subjects were deprived of sleep for one night. Those with endogenous depression\nresponded favourably though the duration of the improvement was variable. In those with\nneurotic depression the response was less reliable and when it occurred the improvement\nwas less marked. In one patient the condition was made worse. Patients with endogenous\ndepression showed a rise in systolic bloodpressure in the ophthalmic artery following sleep\ndeprivation. This did not occur in those with neurotic depression nor in healthy subjects.\nSleep deprivation is to be recommended for the treatment of endogenous depression\nboth in the initial stage and in later stages when the condition has proved resistant to\nthymoleptic agents.<\/jats:p>","DOI":"10.1159\/000468269","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:20:10Z","timestamp":1502472010000},"page":"187-196","source":"Crossref","is-referenced-by-count":144,"title":["Disturbance of the 24-Hour Rhythm in Endogenous Depression\nand the Treatment of Endogenous Depression by Sleep\nDeprivation"],"prefix":"10.1159","author":[{"given":"B.","family":"Pflug","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Tolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["International Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000468269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:47:19Z","timestamp":1777643239000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000468269","archive":["Portico"],"relation":{},"ISSN":["0020-8272","2504-2580"],"issn-type":[{"value":"0020-8272","type":"print"},{"value":"2504-2580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}