{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:17:14Z","timestamp":1777907834121,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Pharmacopsychiatry"],"abstract":"<jats:p>Nomifensine was introduced as an effective antidepressant drug with few\nside effects. However, among our patients we have seen 2 typical cases of drug fever due to\nnomifensine. 2-4 weeks after start of nomifensine treatment, 75-150 mg\/day, for recurrent\nendogenous depressions the patients developed shiverings and fever. Nomifensine was\nwithdrawn and both became afebrile within 1 day. A provocation test with 50 mg nomifensine\np.o. again resulted in shiverings and fever within 6-8 h. 1 of the patients was\nallergic to other drugs and suffered from asthma. During the acute episode of illness the\nserum concentration of alanine aminotransferase was elevated and it normalized after\nstopping the treatment. A liver biopsy at that time showed liver cell necrosis, and a moderate\ngrade of steatosis and fibrosis was also present. The results indicate that nomifensine\nmay cause drug fever. It is possible that patients with allergy and\/or liver diseases in\nparticular may be susceptible to drug fever due to nomifensine.<\/jats:p>","DOI":"10.1159\/000468476","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:20:38Z","timestamp":1502472038000},"page":"66-68","source":"Crossref","is-referenced-by-count":12,"title":["Drug Fever Due to Nomifensine Treatment in Patients\nwith Endogenous Depression"],"prefix":"10.1159","author":[{"given":"Johan","family":"Lanng Nielsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Otto","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["International Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000468476","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:49:17Z","timestamp":1777643357000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468476"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000468476","archive":["Portico"],"relation":{},"ISSN":["0020-8272","2504-2580"],"issn-type":[{"value":"0020-8272","type":"print"},{"value":"2504-2580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}