{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:17:16Z","timestamp":1777907836533,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Pharmacopsychiatry"],"abstract":"<jats:p>50 manic-depressive patients with rapid cycles received lithium for more\nthan 1 year; during depression they received antidepressant drugs. Response was poor in\n36, partial in 6, and good in 8. 21 of the poor responders were persuaded to endure\ndepression without antidepressants; anxiolytics were allowed. 15 stabilized after the end of\nthe untreated depression or after a few milder, shorter episodes; 4 improved partially; 2\nwere unchanged. 15 other rapid cycle patients started on lithium and stopped antidepressants\nat the same time. Response was good in 13, partial in 1, and poor in 1. Patients with a\ncourse of depression-hypomania (or mania)-free interval also responded poorly to prophylactic\nlithium when the depression was treated with antidepressants. They responded well\nwhen antidepressants were withdrawn. Antidepressants often cause or accentuate a switch\nfrom depression to hypomania or mania, and temporary refractoriness to lithium of the\nhypomania or mania. In this way lithium fails to prevent depression.<\/jats:p>","DOI":"10.1159\/000468484","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:20:17Z","timestamp":1502472017000},"page":"124-128","source":"Crossref","is-referenced-by-count":16,"title":["Poor Prophylactic Lithium Response due to\nAntidepressants"],"prefix":"10.1159","author":[{"given":"D.","family":"Reginaldi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Tondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Floris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pignatelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kukopulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["International Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000468484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:49:25Z","timestamp":1777643365000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000468484","archive":["Portico"],"relation":{},"ISSN":["0020-8272","2504-2580"],"issn-type":[{"value":"0020-8272","type":"print"},{"value":"2504-2580","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}