{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:35:25Z","timestamp":1756384525599,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>In 1974, an 8-month-old male was diagnosed with bilateral retinoblastoma. His left eye was enucleated, while the right eye was salvaged with a combination of external beam radiotherapy (4,000 cGy total, divided in 20 fractions) and retinal laser treatment. Thirty-nine years later, he developed intraocular recurrence of retinoblastoma with extrascleral spread. Histopathological examination also identified a second distinct malignancy, retinal pigment epithelium adenocarcinoma, arising in continuity with the retinoblastoma. Further investigation revealed foci of metastatic retinoblastoma in his parotid gland. He was subsequently treated with a combination of orbital exenteration, extensive neck dissection, and resection of metastatic foci, followed by a high-dose ablative chemotherapeutic regimen consisting of cisplatin, vincristine, and cyclophosphamide. Although very rare, late recurrence of retinoblastoma with systemic metastasis is possible, and continued clinical observation and appropriate long-term follow-up should be considered. Additionally, it is important to consider a second primary intraocular tumor in the differential diagnosis, especially in a patient with heritable retinoblastoma who has undergone radiation therapy.<\/jats:p>","DOI":"10.1159\/000468523","type":"journal-article","created":{"date-parts":[[2017,4,13]],"date-time":"2017-04-13T21:01:52Z","timestamp":1492117312000},"page":"296-300","source":"Crossref","is-referenced-by-count":3,"title":["Adenocarcinoma of the Retinal Pigment Epithelium Arising in Conjunction with Late Recurrence and Systemic Metastasis of Retinoblastoma"],"prefix":"10.1159","volume":"3","author":[{"given":"Kelsey","family":"Roelofs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Femida","family":"Kherani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Godfrey","family":"Heathcote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezekiel","family":"Weis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.icu.0000193079.55240.18"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.04.032"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1984.01040030309025"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.044"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e328338676a"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.054"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/01676830600974902"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF02343044"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.119.4.597"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090170094029"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(87)33436-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S59828"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.127886"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(02)01693-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000310"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/468523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/468523","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/468523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:24:06Z","timestamp":1745429046000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,11,28]]},"published-print":{"date-parts":[[2017,11,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000468523","archive":["Portico"],"relation":{},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"type":"print","value":"2296-4681"},{"type":"electronic","value":"2296-4657"}],"subject":[],"published":{"date-parts":[[2017]]}}}