{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:20:32Z","timestamp":1777868432211,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme Protein"],"abstract":"<jats:p>The distributional and activity changes of hypoxanthine guanine\nphosphoribosyltransferase (HGPRT) were investigated\nin the developing mouse brain. The HGPRT activity level was\nlow at birth, increased rapidly during the first 7 days of life,\nand underwent a gradual increase thereafter to the mature level.\nPolyclonal antibody against HGPRT purified from mouse\nbrain was prepared for immunohistochemical demonstration\nof the enzyme during brain development. In the cerebellum,\npart of the Purkinje cells was consistently immunostained\nthroughout growth, and the presence of HGPRT was observed\nin the dendrites of mature Purkinje cells. The most dominant\nchange in HGPRT localization was observed in the hippocampus.\nLittle HGPRT was detectable in the newborn mouse hippocampus.\nAt postnatal day 7, cytoplasmic HGPRT appeared\nsporadically in the granular cells independently of the region\nof the hippocampus. The number of positive immunoreactive\ncells increased with growth, and the dendrites of granular cells\nwere also immunostained on postnatal day 28. Further immunostaining\nwas noted in the granule cells of the dentate gyrus\non postnatal day 35. The above results suggest that HGPRT\nmay play an important role in the developing hippocampus.\nFurther investigations of the HGPRT in the human hippocampus\nmay help to clarify the mechanism underlying the\nneurological disorders encountered in the Lesch-Nyhan syndrome.<\/jats:p>","DOI":"10.1159\/000468659","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:20:45Z","timestamp":1502472045000},"page":"65-72","source":"Crossref","is-referenced-by-count":2,"title":["Postnatal Expression of\nHypoxanthine Guanine\nPhosphoribosyltransferase in the\nMouse Brain"],"prefix":"10.1159","author":[{"given":"Kazumasa","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyoshi","family":"Iida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme and Protein"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000468659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:56:28Z","timestamp":1777550188000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000468659","archive":["Portico"],"relation":{},"ISSN":["1019-6773","2504-2556"],"issn-type":[{"value":"1019-6773","type":"print"},{"value":"2504-2556","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}