{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:20:33Z","timestamp":1777868433493,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme Protein"],"abstract":"<jats:p>Little is known about the kinetics of most serum enzymes during\nthe first hours of life, and even less about the effect on such\nenzyme activities of perinatal hypoxia-ischaemia. It was the\naim of the present study to evaluate the serum kinetics of seven\ndifferently located cell enzymes in healthy and asphyxiated\nnewborns during the 1st week of life. The serum activities of\ncytoplasmic and mitochondrial [aspartate aminotransferase\n(ASAT), creatine kinase (CK), glutamate dehydrogenase\n(GLDH), lactate dehydrogenase (LDH), and hydroxybutyrate\ndehydrogenase (HBDH)] and membrane-bound (\u03b3-glutamyltransferase\nand leucine arylaminidase) enzymes were prospectively\nmeasured in full-term asphyxiated (n = 49) and healthy\n(n = 87) newborns during the first 144 h of life. The blood samples\nwere taken serially at five fixed times; 0 (cord), 12,24,72,\nand 144 h postpartum. The asphyxiated newborns had significantly\nincreased serum activities of ASAT, LDH, and HBDH\nup to 72 h postpartum, whereas healthy newborns showed\nhigher CK and GLDH activities. Only the activities of ASAT,\nLDH, and HBDH seemed to depend on the oxygen supply of\nthe fetus or newborn. If other causes of increased serum\nenzyme activities, e.g. liver diseases, haemolytic disorders,\ntumours, or inborn errors of metabolism, are excluded, elevated\nserum activities of ASAT, LDH, and HBDH should\ndraw one\u2019s attention to a perinatal hypoxic-ischaemic insult of\nthe newborn.<\/jats:p>","DOI":"10.1159\/000468672","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:21:06Z","timestamp":1502472066000},"page":"160-172","source":"Crossref","is-referenced-by-count":30,"title":["Serum Enzyme Activities in Full-Term Asphyxiated and Healthy Newborns: Enzyme Kinetics during the First 144 Hours of Life"],"prefix":"10.1159","author":[{"given":"Gerd M.","family":"Lackmann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"T\u00f6llner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Mader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme and Protein"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000468672","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T11:56:31Z","timestamp":1777550191000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000468672","archive":["Portico"],"relation":{},"ISSN":["1019-6773","2504-2556"],"issn-type":[{"value":"1019-6773","type":"print"},{"value":"2504-2556","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}