{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:16Z","timestamp":1777868836741,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Anaphylactic shock was induced in rabbits by injecting bovine serum albumin\n(BSA) as an antigen. Measurements of the enzyme activities in the fibrinolytic system confirmed\nthat a rapid and strong increase of plasminogen activator (PA) was induced during\nanaphylaxis. The euglobulin fibrinolytic activity (EFA) as estimated by the plasminogen-rich\nfibrin plate method rose significantly, peaking at 15 min after the BSA injection (when the\narterial pressure was minimum). However, EFA was not detected by the plasminogen-poor\nfibrin plate method. The tissue-type PA (t-PA) activity using the natural substrate plasminogen\nincreased significantly with a peak at 15 min. The amidolytic activity also simultaneously\nincreased significantly using the t-PA substrate, H-D-Ile-Pro-Arg-pNA. The plasminogen\nactivator inhibitor (PAI) activity remained at baseline levels until 30 min, but rose\nfourfold at 90 min. The main plasma fibrinolytic enzyme which increased in anaphylaxis was\nproved by zymography to be t-PA with a molecular weight (MW) of 69,000.<\/jats:p>","DOI":"10.1159\/000468789","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:21:07Z","timestamp":1502472067000},"page":"204-212","source":"Crossref","is-referenced-by-count":3,"title":["A Rapid and Strong Increase of Plasminogen Activator Induced\nby Experimental Anaphylaxis in Rabbits"],"prefix":"10.1159","author":[{"given":"Kazuhiro","family":"Shimaya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Sumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masugi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000468789","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:45:42Z","timestamp":1777553142000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000468789","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}