{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:17Z","timestamp":1777868837663,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>We measured the cholinesterase activity in morning urines from 63 insulindependent\ndiabetics and 27 controls. The total esterase (TotE) activity (Ellman\u2019s method) has\nbeen divided into aliesterase (AliE), pseudocholinesterase and acetylcholinesterase by means of\ntwo inhibitors, eserine and quinidine. Diabetics were divided in 2 groups according to the\nurinary albumin\/creatinine ratio (mg\/mmol, &lt; 2 in group 1, &gt; 2 in group 2). The urinary\ncholinesterase behavior was correlated with that of a known tubular lysosomal hydrolase,\nN-acetyl-\u03b2-D-glucosaminidase (NAG). Compared to normals, in addition to a significant\nincrease in urinary NAG in diabetics (in group 2 more than in group 1 ), TotE and AliE were also\nsignificantly raised (+36% and 109% of the controls, in group 1 as much as in group 2).<\/jats:p>","DOI":"10.1159\/000468810","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:21:13Z","timestamp":1502472073000},"page":"315-318","source":"Crossref","is-referenced-by-count":2,"title":["Urinary Cholinesterase Activity Is Increased in\nInsulin-Dependent Diabetics:\nFurther Evidence of Diabetic Tubular Dysfunction"],"prefix":"10.1159","author":[{"given":"E.","family":"Matteucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Uncini-Manganelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Cecere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Saviozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Giampietro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000468810","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:45:49Z","timestamp":1777553149000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468810"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000468810","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}