{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:20Z","timestamp":1777868840693,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Guanidino compounds, intermediates of arginine metabolism, are altered in\nmany pathological conditions especially those involving the urea cycle. Arginine and creatine\nplay an important role in nitrogen metabolism whereas other guanidino compounds such as\nguanidinosuccinic acid and N-acetylarginine are toxins. Our objective was to investigate the\nrelationship between guanidino compounds and hyperammonemia. Young and adult ferrets\nwere fed a single meal of either an arginine-containing diet (ACD) or an arginine-free diet\n(AFD). Guanidino compounds were determined by HPLC in the plasma, liver, kidney and\nbrain 3 h after feeding the specified diet. Only young ferrets fed AFD developed hyperammonemia.\nPlasma and kidney arginine was decreased whereas guanidinosuccinic acid was\nincreased in young ferrets fed AFD. Hepatic creatine and kidney and brain guanidinoacetic\nacid were significantly decreased in this group. These results indicate that AFD-induced\nhyperammonemia produced decreased m\u00e9thylation activity in the liver and transamidination\nactivity in kidney. Elevated guanidinosuccinate levels coupled with deficient hepatic\ncreatine synthesis may play a role in the pathophysiology of hyperammonemia.<\/jats:p>","DOI":"10.1159\/000468879","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:21:32Z","timestamp":1502472092000},"page":"128-136","source":"Crossref","is-referenced-by-count":6,"title":["Guanidino Compound Metabolism in Arginine-Free Diet\nInduced Hyperammonemia"],"prefix":"10.1159","author":[{"given":"Devendra R.","family":"Deshmukh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Meert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.P.","family":"Sarnaik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"Marescau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P.","family":"DeDeyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000468879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:46:00Z","timestamp":1777553160000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000468879","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}