{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:21Z","timestamp":1777868841391,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Acute mitochondrial insult has been suggested as a primary reason for the clinical,\nhistopathological and biochemical abnormalities seen in Reye\u2019s syndrome. However,\nthe etiology of mitochondrial dysfunction has not been identified. Polyamines have been\nknown to alter the mitochondrial structure and function. Influenza infection may cause an\nincrease in ornithine decarboxylase activity and thereby channel ornithine for polyamine\nbiosynthesis, leading to mitochondrial dysfunction in Reye\u2019s syndrome. To test this hypothesis,\nthe hepatic concentrations of polyamines, polyamine-metabolizing enzymes and urea\ncycle enzyme activities in Reye\u2019s syndrome patients were determined and compared with\npatients who died from illnesses other than Reye\u2019s syndrome. The hepatic concentration of\nputrescine, spermidine and spermine were increased in Reye\u2019s syndrome patients. The activity\nof ornithine decarboxylase was elevated but, due to the small nubmer of samples, these\nvalues did not reach statistical significance. Ornithine carbamoyltransferase activity was\ndecreased in the liver of Reye\u2019s syndrome patients. Our results suggest that increased synthesis\nof polyamines from ornithine may initiate mitochondrial injury in Reye\u2019s syndrome.<\/jats:p>","DOI":"10.1159\/000468891","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:21:51Z","timestamp":1502472111000},"page":"209-214","source":"Crossref","is-referenced-by-count":1,"title":["Hepatic Polyamine Metabolism in Children with\nReye\u2019s Syndrome"],"prefix":"10.1159","author":[{"given":"Arindam","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devendra R.","family":"Deshmukh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashok P.","family":"Sarnaik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000468891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:46:00Z","timestamp":1777553160000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000468891","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}