{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:10:19Z","timestamp":1791951019303,"version":"4.3.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Background: The association of polyomaviruses BK and JC with other opportunistic infections and graft-versus-host disease (GvHD) in allogeneic stem cell transplantation is controversially discussed. Methods: We conducted a retrospective study of 64 adult patients who received their first allogeneic stem cell transplantation between March 2010 and December 2014; the follow-up time was 2 years. Results: Acute leukemia was the most frequent underlying disease (45.3%), and conditioning included myeloablative (67.2%) and nonmyeloablative protocols (32.8%). All patients received 10 mg of alemtuzumab on day -2 (20 mg in case of mismatch) as GvHD prophylaxis. Twenty-seven patients (41.5%) developed cytomegalovirus (CMV) reactivation. BKPyV-associated hemorrhagic cystitis was diagnosed in 10 patients (15.6%). Other opportunistic infections caused by viruses or protozoa occurred rarely (&lt;10%). There was no association of BKPyV or JCPyV with CMV reactivation, Epstein-Barr virus reactivation, human herpes virus 6, or parvovirus B19 infection requiring treatment. There was a significant correlation of BKPyV-associated hemorrhagic cystitis with toxoplasmosis (p = 0.013). Additionally, there was a significant link of simultaneous BKPyV and JCPyV viruria with toxoplasmosis (p = 0.047). BKPyV and JCPyV were not associated with GvHD, relapse, or death. Conclusion: We found no association of BKPyV or JCPyV with viral infections or GvHD. Only the correlation of both polyomaviruses with toxoplasmosis was significant. This is a novel and interesting finding.<\/jats:p>","DOI":"10.1159\/000468972","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T21:01:32Z","timestamp":1496869292000},"page":"3-9","source":"Crossref","is-referenced-by-count":6,"title":["Are the Polyomaviruses BK and JC Associated with Opportunistic Infections, Graft-versus-Host Disease, or Worse Outcomes in Adult Patients Receiving Their First Allogeneic Stem Cell Transplantation with Low-Dose Alemtuzumab?"],"prefix":"10.1159","volume":"138","author":[{"given":"Laila","family":"Schneidewind","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Knoll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Smola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Andreas","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701555"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.11.5394-5396.2004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000165110.78397.93"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1108"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13635"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2013.235"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086\/510388"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2015.09.039"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3046.2010.01325.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12233"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-016-0872-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-12-181"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.181"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182a6890d"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/tid.12364"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000445124"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/aha\/article-pdf\/138\/1\/3\/3895896\/000468972.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/aha\/article-pdf\/138\/1\/3\/3895896\/000468972.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:28:31Z","timestamp":1745429311000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000468972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,8,25]]},"published-print":{"date-parts":[[2017,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000468972","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}