{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:23Z","timestamp":1777868843887,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Sporidesmin, a hepatotoxin from Pithomyces chartarum, is responsible for\nfacial eczema in ruminants. In an attempt to clarify the biochemical processes supporting\nsporidesmin toxicity and response of the liver, haematology, plasma biochemistry and liver\nenzyme changes were monitored for 21 days in a model for facial eczema resulting from a\nsingle intraperitoneal injection of 2.8 mg\/kg BW sporidesmin to guinea pigs. Most plasma\ndisturbances were observed 8 days after administration and accounted for starvation, liver\ncytolysis, and cholestasis or liver enzyme induction. Alterations of hepatic enzyme activities\nwere intense with a maximum increase on days 2 for alkaline phosphatases (ALP) and 8 for\n\u03b3-glutamyltransferase (GGT), and a maximum decrease on day 21 for aspartate aminotransferase\n(ASAT) and alanine aminotransferase (ALAT). Comparison of liver and plasma\nenzyme changes indicates that GGT was the most reliable and significant plasma indicator of\nsporidesmin-associated liver alterations. Moreover, this study points out the validity of the\none-dose intoxicated guinea-pig model for research on sporidesmin biochemical toxicity and\npathobiology of facial eczema.<\/jats:p>","DOI":"10.1159\/000469005","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:21:54Z","timestamp":1502472114000},"page":"39-46","source":"Crossref","is-referenced-by-count":2,"title":["Liver Enzyme Changes in a Guinea-Pig Model of Facial\nEczema (Sporidesmiotoxicosis)"],"prefix":"10.1159","author":[{"given":"M.","family":"Bonnefoi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hasim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Sauvagnac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Burgat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:46:08Z","timestamp":1777553168000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469005","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}