{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:25Z","timestamp":1777868845671,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>\u03b2-Hexosaminidase (Hex) activity was previously found to be increased in the\nsera of patients with liver cirrhosis, cholestasis and acute alcohol intoxication, as well as in\nrats with CCL(4)-induced liver cirrhosis. We studied this enzymatic activity in the sera and\nliver tissue of rats with alcoholic fatty liver due to prolonged alcohol intake and CCl(4-)\ninduced liver fibrosis in association with moderate alterations in liver function tests. Serum\nand liver Hex activity did not show any significant change in both experimental models.\nThese data suggest that Hex is not an alcohol-induced enzyme, and that severe, but not\nmoderate, liver damage can determine the increase in this lysosomal enzymatic activity.<\/jats:p>","DOI":"10.1159\/000469011","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:21:40Z","timestamp":1502472100000},"page":"68-72","source":"Crossref","is-referenced-by-count":1,"title":["\u03b2-Hexosaminidase Activity in Alcoholic Fatty Liver and in\nCCL-Induced Liver Fibrosis of the Rat"],"prefix":"10.1159","author":[{"given":"S.","family":"Antoniello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Auletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Vatiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Nigro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Cacciatore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:46:17Z","timestamp":1777553177000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469011","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}