{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:26Z","timestamp":1777868846980,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>We studied the relationship between the ratio of serum aspartate aminotransferase\n(ASAT) to alanine aminotransferase (ALAT) and histologic changes in human and\nexperimental alcoholic liver disease. The patient population included 52 hospitalized\npatients enrolled in a Veterans Administration Cooperative study. The experimental animal\ngroup consisted of male Wistar rats fed an ethanol-liquid diet. Of the 52 patients with\nalcoholic hepatitis, 33 had evidence of cirrhosis. The mean \u00b1 SD for the ASAT\/ALAT ratio\nin the group with alcoholic hepatitis and no cirrhosis was 1.47 \u00b1 0.84, the mean \u00b1 SD in the\ngroup with hepatitis and cirrhosis was significantly higher (2.68 \u00b1 1.32, p &lt; 0.01). There\nwas no difference in the ratio between the rats with and without liver fibrosis. The cause for\nthe increased AS AT\/ALAT ratio in serum in the presence of cirrhosis is unknown and may\nreflect more severe liver damage.<\/jats:p>","DOI":"10.1159\/000469062","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:21:45Z","timestamp":1502472105000},"page":"112-115","source":"Crossref","is-referenced-by-count":9,"title":["Serum Aspartate Aminotransferase to Alanine\nAminotransferase Ratio in Human and Experimental Alcoholic\nLiver Disease: Relationship to Histologic Changes"],"prefix":"10.1159","author":[{"given":"A. A.","family":"Nanji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. W.","family":"French","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L","family":"Mendenhall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:46:32Z","timestamp":1777553192000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469062","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}