{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:28Z","timestamp":1777868848965,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>This study reports on basal gastric pepsins in 40 normal, kwashiorkor and\nmarasmic children admitted to the paediatric wards of the University of Benin Teaching\nHospital, Nigeria. The activity of total pepsin was significantly depressed in the diseased\nstates. The various fractions of pepsin separated on ion-exchange chromatography also\nshowed dramatic reductions for both kwashiorkor and marasmus. This adaptive reduction of\npepsin and its fractions was more drastic in marasmus than kwashiorkor. On disc-gel electrophoresis,\nfour of the pepsin bands found in normal gastric aspirate were missing in children\nwith the syndromes. Gastric electrolytes and acidity recorded for the diseased states\nwere not conducive for maximal peptic activity. It is suggested that due to the reduced\nproteolytic capability of the malnourished infants, rehabilitation with intact protein should\nbe cautious and gradual.<\/jats:p>","DOI":"10.1159\/000469092","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:04Z","timestamp":1502472124000},"page":"44-49","source":"Crossref","is-referenced-by-count":0,"title":["Pepsins in Protein-Energy Malnutrition"],"prefix":"10.1159","author":[{"given":"I.","family":"Adamson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Esangbedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Abiodun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:46:41Z","timestamp":1777553201000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469092","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}