{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:34Z","timestamp":1777868854371,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Fibrinolysis, the body\u2019s ability to degrade fibrin, is an integrated part of hemostasis.\nOveractivity in the fibrinolytic system causes bleeding and underactivity causes thrombosis.\nTissue plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1),\n&lt;X2-antiplasmin (\u03b1(2)-AP) and plasminogen are definitely involved in fibrinolysis because:\n(1) these components can be assigned a fibrinolytic role in purified systems, i.e. in vitro, and\n(2) abnormal structural variants and abnormal levels of these components give rise to bleeding\nor to thrombosis. The biological control of tPA-mediated fibrinolysis is both cellular and\nhumoral. The cellular regulation compasses synthesis of tPA and PAI-1 and release\/uptake of\nthese components. The humoral regulation involves: (1) the reaction between tPA and PAI-1;\n(2) the fibrin-stimulated plasminogen activation; (3) the reaction between plasmin and \u03b1(2)-AP\nand (4) plasmin degradation of fibrin. The highly developed biological control of tPAmediated\nfibrinolysis is indicative of its physiological importance.<\/jats:p>","DOI":"10.1159\/000469155","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:15Z","timestamp":1502472135000},"page":"130-143","source":"Crossref","is-referenced-by-count":28,"title":["Biological Control of Tissue Plasminogen Activator-Mediated\nFibrinolysis"],"prefix":"10.1159","author":[{"given":"Mats","family":"R\u00e5anby","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Br\u00e4ndstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:47:08Z","timestamp":1777553228000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469155","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}