{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:33Z","timestamp":1777868853866,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Thrombin inhibitors have recently advanced to the stage of preclinical testing as\nanticoagulants. However, little is known about the effects of these inhibitors on the enzymes\nof the fibrinolytic system. In the present study we evaluated the effect of two protein and two\nsynthetic inhibitors of thrombin on tissue plasminogen activator (tPA), urokinase, and plasmin.\nWe found that hirudin inhibited the amidolytic activity of plasmin but had no effect on\ntPA or urokinase. Antithrombin III inhibited plasmin and urokinase but had no effect on\ntPA. D-Phe-Pro-Arg-CH(2)Cl inhibited plasmin and tPA but had no effect on urokinase.\nThromstop inhibited all three fibrinolytic enzymes: plasmin, urokinase, and tPA. Thus each\nthrombin inhibitor tested had different inhibitory effects on the fibrinolytic enzymes. These\neffects should be carefully considered when thrombin inhibitors are used as antithrombotic\ndrugs.<\/jats:p>","DOI":"10.1159\/000469156","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:15Z","timestamp":1502472135000},"page":"144-148","source":"Crossref","is-referenced-by-count":12,"title":["Inhibition of Fibrinolytic Enzymes by Thrombin Inhibitors"],"prefix":"10.1159","author":[{"given":"N.","family":"Gilboa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. B","family":"Villannueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Fenton, II","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:47:07Z","timestamp":1777553227000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469156","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}