{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:45Z","timestamp":1777868865809,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Advances in our knowledge of the microsomal metabolism of ethanol enable us\nto understand a number of complications that develop in the alcoholic. After chronic ethanol\nconsumption, microsomal ethanol-oxidizing system (MEOS) activity increases with an associated\nrise in microsomal cytochrome P-450, including a form different from that induced by\nph\u00e9nobarbital and methylcholanthrene and which has a high affinity for ethanol, as shown in\nreconstituted systems. The role of this MEOS in vivo and its increase after chronic ethanol\nconsumption was most conclusively shown in alcohol dehydrogenase-negative deer mice.\nMicrosomal induction is also associated with enhanced metabolism of other drugs, resulting\nin metabolic drug tolerance. Futhermore, there is increased conversion to toxic metabolites\nof known hepatotoxic agents (such as CC1(4)), which may explain the enhanced susceptibility\nof alcoholics to the toxicity of industrial solvents. Furthermore, the ethanol-induced form of\ncytochrome P-450 has a high capacity for the conversion to toxic metabolites of some commonly\nused drugs, such as acetaminophen, and also carcinogens, such as dimethylnitrosamine\nwhich is activated at concentrations much lower than those required for other microsomal\ninducers. Moreover, catabolism of retinol is accelerated through a newly discovered\nmicrosomal pathway, thereby contributing to hepatic vitamin A depletion and possibly vitamin\nA toxicity. There is also induction of microsomal enzymes involved in lipoprotein\nproduction, resulting in hyperlipemia. Contrasting with the chronic effects of ethanol consumption,\nacutely, ethanol inhibits the metabolism of other drugs through competition for\nan at least partially shared microsomal detoxification pathway.<\/jats:p>","DOI":"10.1159\/000469240","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:19Z","timestamp":1502472139000},"page":"45-56","source":"Crossref","is-referenced-by-count":31,"title":["Microsomal Ethanol-Oxidizing System"],"prefix":"10.1159","author":[{"given":"C. S.","family":"Lieber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:47:43Z","timestamp":1777553263000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469240","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}