{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:50:38Z","timestamp":1784310638536,"version":"3.55.0"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Lipoperoxidation, a degradative process of membranous polyunsaturated fatty\nacids, has been suggested to represent an important mechanism in the pathogenesis of ethanol\ntoxicity on the liver and possibly also on the brain. Catalysis by transition metals, especially\niron, is involved in the biosynthesis of free radicals contributing to lipid peroxidation.\nAlthough the exact nature of the redox-active iron implicated in this catalysis is still\nunknown, it has been well established that lipid peroxidation can be prevented in vitro by\niron chelators such as desferrioxamine. Deprivation of redox-active iron through desferrioxamine\ninhibits by about 50% the microsomal oxidation of ethanol in vitro and reduces very\nsignificantly in vivo the overall ethanol elimination rate in rats. Administration of desferrioxamine\ntogether with ethanol also reduces the ethanol-induced disturbances in the antioxidant\ndefense mechanisms of the hepatocyte. It also reduces in mice both the severity of\nphysical dependence on ethanol and lethality following the acute administration of a narcotic\ndose of ethanol. Chronic overloading of rats with iron results, on the opposite, in an\nincreased rate of ethanol elimination, although alcohol dehydrogenase and catalase activities\nare reduced and cytochrome P-450 depleted in the liver of such iron-overloaded animals.\nThe magnitude of the ethanol-induced increase in lipid peroxidation and decrease in the\nmajor membranous antioxidant, a-tocopherol, is exacerbated in iron-overloaded rats. Several\ndisturbances of iron metabolism have been reported in human alcoholics. Their contribution\nto ethanol toxicity appears very likely in the case of hepatic siderosis associated with\nalcohol abuse. Ethanol could however disturb iron metabolism even in the absence of gross\nabnormalities of the total iron stores. It is suggested that ethanol intoxication could increase\ncellular redox-active iron, thus contributing to an enhanced steady-state concentration of\nreactive-free radicals. This oxidative stress would lead to lipoperoxidative damage and cellular\ninjury.<\/jats:p>","DOI":"10.1159\/000469241","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:19Z","timestamp":1502472139000},"page":"57-69","source":"Crossref","is-referenced-by-count":51,"title":["Involvement of Iron and Iron-Catalyzed Free Radical\nProduction in Ethanol Metabolism and Toxicity"],"prefix":"10.1159","author":[{"given":"Roger","family":"Nordmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ribi\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Rouach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:47:47Z","timestamp":1777553267000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469241","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}