{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:49Z","timestamp":1777868869739,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Glutamine, the principal source of urinary ammonia, can be fully oxidized or\nconverted to glucose by the kidney. To be oxidized, the carbon skeleton of glutamine must\nenter the TCA cycle as acetyl CoA formed by pyruvate dehydrogenase (PDH). The purpose\nof this study was to measure kidney PDH activity (active and total) following acute acid-base\nchanges in vivo. PDHa activity was elevated after acute metabolic alkalosis and acidosis and\nunchanged by respiratory acidosis. Kidney ADP\/ATP, CoA\/acetyl CoA and calculated mitochondrial\nNADVNADH ratios were also determined and revealed an increase in kidney\nADP\/ATP with alkalosis but no changes during metabolic and respiratory acidosis.<\/jats:p>","DOI":"10.1159\/000469249","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:06Z","timestamp":1502472126000},"page":"127-133","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Acute Acid-Base Changes on Rat Renal Pyruvate\nDehydrogenase"],"prefix":"10.1159","author":[{"given":"Peter C.","family":"Tullson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469249","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:47:48Z","timestamp":1777553268000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469249","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}