{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:52Z","timestamp":1777868872148,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Analysis of data on 9 cases with active cytomegalovirus infection in patients\nwith kidney grafts showed a positive association of serum leucine aminopeptidase activity\nconcentration with the appearance of plasmacytoid lymphocytes in blood. Additional studies\nindicate that (1) like the liver, the lymphocytes contain leucine aminopeptidase in relatively\nlarge quantities and that (2) this enzyme is increased about 3-fold in plasmacytoid lymphocytes\nwhen compared with the activity in normal lymphocytes. In contrast, the \u2018hepatic\u2019\nenzyme alanine aminotransferase is practically absent in both lymphocytes and plasmacytoid\ncells. Therefore, the difference in serum between the relative increases of leucine aminopeptidase\nand alanine aminotransferase may be attributed to proliferating plasmacytoid\nlymphocytes. Earlier observations on a large number of cases of acute viral hepatitis A or B\nlend credence to this assumption. However, in this disease, the serum enzyme changes reflect\nthe much greater involvement of the liver and the relatively slight, but significant, proliferation\nof plasmacytoid lymphocytes. Our hypothesis is confirmed by the recent observation of\n3 cases of acute EBV infection (infectious mononucleosis) in otherwise healthy individuals\nshowing greatly elevated leucine aminopeptidase in contrast to normal or slightly raised\nalanine aminotransferase in serum.<\/jats:p>","DOI":"10.1159\/000469290","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:11Z","timestamp":1502472131000},"page":"179-186","source":"Crossref","is-referenced-by-count":2,"title":["Serum Leucine Aminopeptidase for Monitoring Viral\nInfections with Plasmacytoid Reaction"],"prefix":"10.1159","author":[{"given":"Raina","family":"Pancheva-Haschen (a)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Haschen (b)","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:48:03Z","timestamp":1777553283000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469290","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}