{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:51Z","timestamp":1777868871576,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Since organotin compounds represent an environmental health hazard, we determined\nthe effect of triethyltin bromide (TTB) on red blood cell (RBC) enzyme activity. TTB\nproduced a concentration-dependent inhibition of hexokinase and pyrimidine 5'-nucleotidasc\nfor both adult and cord RBC. D-Glucose, but not ATP or MgCl(2), prevented the hexokinase\ninhibition by TTB. Glucose-6-phosphate dehydrogenase, adenylate kinase, and hypoxanthine-\nguanine phosphoribosyltransferase were also inhibited by TTB. Cord RBC enzymes\nwere more resistant to the effects of TTB than were adult RBC enzymes. Although TTB is a\npotent inhibitor of hexokinase, physiologic concentrations of glucose appear to protect the\nRBC during clinical tin intoxication.<\/jats:p>","DOI":"10.1159\/000469327","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:31Z","timestamp":1502472151000},"page":"87-95","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Triethyltin on Enzyme Activity in Human Adult and\nCord Red Cells"],"prefix":"10.1159","author":[{"given":"Nilsa","family":"Patritti-Laborde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil A.","family":"Lachant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Tomoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Ha","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:48:16Z","timestamp":1777553296000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469327","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}