{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:54Z","timestamp":1777868874628,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Studies were carried out on erythrocytes and fibroblasts from a 3-year-old white\nmale with severe glucose-6-phosphate dehydrogenase (G6PD) deficiency and chronic nonspherocytic\nhemolytic anemia. Red blood cell G6PD activity was less than 0.02% of normal\nvalues. Since the child\u2019s fibroblasts had 2-4% of normal enzymic activity, they were utilized\nas a source of enzyme for kinetic studies. The G6PD demonstrated marked heat lability, a\nnormal K(m) value forglucose-6-phosphate (56 \u03bcmol\/1), a nearly normal pH-activity curve, and\nincreased utilization of 2-deoxyglucose-6-phosphate (76% of the rate with glucose-6-phosphatc).\nThese studies clearly indicate that this is a new molecular variant (G6PD Beaumont).<\/jats:p>","DOI":"10.1159\/000469354","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:43Z","timestamp":1502472163000},"page":"15-21","source":"Crossref","is-referenced-by-count":2,"title":["Glucose-6-Phosphate Dehydrogenase Beaumont:\nA New Variant with Severe Enzyme Deficiency and Chronic\nNonspherocytic Hemolytic Anemia"],"prefix":"10.1159","author":[{"given":"Robert J.","family":"Mamlok","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon C.","family":"Mills","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall M.","family":"Goldblum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles W.","family":"Daeschner III","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:48:24Z","timestamp":1777553304000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469354","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}