{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:58Z","timestamp":1777868878293,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Plasma levels of the lysosomal enzymes, \u00df-hexosaminidase and \u00df-glucuronidase,\nwere analyzed in rats with carbon tetrachloride induced liver cirrhosis. Out of 22 animals, 15\nshowed cirrhotic and 4 precirrhotic livers. 4 cirrhotic animals exhibited cholestatic features\nwith increased bilirubin, alkaline phosphatase (ALP) and aspartate aminotransferase (ASAT)\nin plasma. The remaining 15 precirrhotic and cirrhotic rats showed clear significant changes\nonly in ASAT levels. These 15 rats showed no consistent increase in plasma, spleen or liver\nlysosomal enzyme activities, whereas the 4 rats with cholestatic features exhibited considerable\nincreases of lysosomal enzymes. The increased activities might be attributed to decreased\nbiliary excretion and\/or increased production of lysosomal enzymes by activated macrophages.<\/jats:p>","DOI":"10.1159\/000469411","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:44Z","timestamp":1502472164000},"page":"84-88","source":"Crossref","is-referenced-by-count":11,"title":["Lysosomal Enzymes in Plasma, Liver and Spleen from\nRats with Carbon Tetrachloride-Induced Liver Cirrhosis"],"prefix":"10.1159","author":[{"given":"K.","family":"Mel\u00e9n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Hultberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"H\u00e4gerstrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Isaksson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Joelsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bengmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:48:49Z","timestamp":1777553329000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469411","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}