{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:27:58Z","timestamp":1777868878554,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>We reviewed charts of 38 Patients who developed cholestasis whilst receiving\ntotal parenteral nutrition (TPN). A standard protocol was followed for administration of TPN\nand included crystalline amino acid solution with lipid emulsion and dextrose as calorie\nsources. 5 of the 38 patients did not exhibit an increase in alkaline phosphatase. This may be\nrelated to the concomitant low levels of either serum zinc or magnesium or both. We also\nobtained a positive correlation between serum levels of zinc and magnesium and the peak\nactivity of alkaline phosphatase (r = 0.49, p &lt; 0.01, r-0.55, p &lt; 0.01, respectively) associated\nwith cholestasis. We hypothesize that the reason for this association is related to both zinc and\nmagnesium being activators of alkaline phosphatase activity.<\/jats:p>","DOI":"10.1159\/000469414","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:44Z","timestamp":1502472164000},"page":"101-104","source":"Crossref","is-referenced-by-count":2,"title":["Absence of Increase of Serum Alkaline Phosphatase Activity\nwith Parenteral Nutrition-Associated Cholestasis:\nPossible Consequence of Hypozincemia and Hypomagnesemia"],"prefix":"10.1159","author":[{"given":"Amin A.","family":"Nanji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:48:49Z","timestamp":1777553329000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469414","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}