{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:28:03Z","timestamp":1777868883699,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Berenil (4,4-diamidinodiazoaminobenzene-diacetamide acetate) or Suramin [sodium\nsalt of 8-(3-benzamido-4-methylbenzamido)-naphthalene-l,3,5-trisulfonic acid] treatment\nof rats infected with Trypanosoma b. brucei enhanced hepatic microsomal aniline\nhydroxylase and p-aminopyrine N-demethylase activities. While Suramin inhibited significantly\nthe activities of cytoplasmic glutamate dehydrogenase and lactate dehydrogenase, Berenil\nhad no effect. The kinetic profiles of these enzymes consistently showed a K(m) value\nsimilar to that of controls. Both cytosolic and microsomal glutathione-S transferase and\nmicrosomal epoxide hydratase were unaffected by Suramin. However, a significant increase in\ncytosolic glutathione-S transferase was observed with Berenil. Microsomal phospholipids\nwere not affected by any of the drugs.<\/jats:p>","DOI":"10.1159\/000469515","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:59Z","timestamp":1502472179000},"page":"129-136","source":"Crossref","is-referenced-by-count":2,"title":["Response of the Rat\u2019s Hepatic Drug-Metabolizing Enzyme\nSystem to Chemotherapy of Trypanosoma b. brucei Infections\nwith Berenil and Suramin"],"prefix":"10.1159","author":[{"given":"Godwin O.","family":"Emerole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. I.","family":"Thabrew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:49:15Z","timestamp":1777553355000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469515","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}