{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:28:08Z","timestamp":1777868888156,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>The effect of vitamin A deficiency on the drug-metabolizing enzyme system of\nthe lung and liver was analyzed in rats fed diets with or without vitamin A for 5-6 weeks. The\nhepatic level of vitamin A was significantly reduced in vitamin A deficient animals. The\nhepatic cytochrome P-450 and b(5) contents and activity of benzo(a)pyrene hydroxylase was\nsignificantly reduced in deficient animals. Contrary to this, pulmonary cytochrome P-450 and\nb(5) contents were above the control values. No alteration in pulmonary benzo(a)pyrene\nhydroxylase was noted. The uridine diphosphate-glucuronosyltransferase activity of digitonin-\ntreated microsomal membranes was below the control values both in lung and liver.\nHowever, the native uridine diphosphate-glucuronosyltransferase activity remained unchanged\nin the liver and was below control values in the lung.<\/jats:p>","DOI":"10.1159\/000469557","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:23:07Z","timestamp":1502472187000},"page":"99-104","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Vitamin A Deficiency on the Pulmonary and Hepatic\nDrug-Metabolizing Enzymes in Rat"],"prefix":"10.1159","author":[{"given":"S.C.","family":"Dogra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.L.","family":"Khanduja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.R.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:49:33Z","timestamp":1777553373000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469557","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}