{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:28:09Z","timestamp":1777868889436,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>Some authors have suggested that carbohydrates can induce hepatic microsomal\nenzymes, resulting in increased serum \u03b3-glutamyltransferase (GGT) in diabetes mellitus. Previously\nwe demonstrated the lack of serum GGT increases in patients with acute diabetic\ncrises. In this work we studied serum GGT activity, blood glucose levels and glycosylated\nhemoglobin levels (HB A(1)) in 35 patients with diabetes mellitus and 27 healthy volunteers.\nWe did not see differences in the serum GGT activity among controlled (25.05 \u00b1 2.72 U\/l) and\nuncontrolled (26.44 \u00b1 4.05 U\/l) diabetics and the control group (22.51 \u00b1 2.95 U\/l). Also, there\nwas no significant correlation between serum GGT and HB A(1) levels in diabetic patients (r =\n0.279). We think that our observations may be relevant because they support the hypothesis\nthat hyperglycemia does not act as an enzyme-inducing agent in chronically uncontrolled\ndiabetics and, furthermore, they indicate that in the presence of abnormal serum GGT levels\nin diabetics it is necessary to investigate other associated diseases.<\/jats:p>","DOI":"10.1159\/000469590","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:22:53Z","timestamp":1502472173000},"page":"277-281","source":"Crossref","is-referenced-by-count":2,"title":["Lack of Induction of Serum Gamma-Glutamyltransferase in\nDiabetes mellitus"],"prefix":"10.1159","author":[{"given":"J.","family":"Jimenez-Alonso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Jaimez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Perez-Jimenez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bejarano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.A.","family":"Jimenez-Pereperez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:49:45Z","timestamp":1777553385000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469590","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}