{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T04:28:13Z","timestamp":1777868893660,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T00:00:00Z","timestamp":1502409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Enzyme"],"abstract":"<jats:p>The effect of castration of male rats with experimental renal hypertension (\u2018two kidney\nGoldblatt hypertension\u2019) was studied on the height of the hypertension and on the\nurinary output of \u03b3-glutamyl transpeptidase (\u03b3GT) and of N-acetyl-beta-D-glucosaminidase\n(NAG). Castration was carried out immediately after clamping one renal artery. Some of the\ncastrates received testosterone substitution from the 3rd postoperative week onwards. Uncastrated\nhypertensive males served as controls. The experiments were carried out 8-18 weeks\nafter eliciting high blood pressure. Hypertension as well as enzymuria were less expressed in\ncastrates than in uncastrated males or in testosterone-substituted rats. In all animals studied\nthe \u03b3GT excretion rate showed a positive correlation with the blood pressure. The output of\n\u03b3GT and of NAG as well as the specific \u03b3GT activity of the renal membrane fraction was\nlower in castrates than in uncastrated males or in substituted castrates. In uncastrated males\nand in testosterone-substituted castrates the daily NAG output showed a direct correlation\nwith the renal hydroxyproline content. No such correlation was found in castrated males. The\nkidneys of castrates and of testosterone-substituted castrates contained less hydroxyproline\nthan those of uncastrated males.<\/jats:p>","DOI":"10.1159\/000469613","type":"journal-article","created":{"date-parts":[[2017,8,11]],"date-time":"2017-08-11T17:23:05Z","timestamp":1502472185000},"page":"93-99","source":"Crossref","is-referenced-by-count":7,"title":["Effect of Castration and Testosterone Substitution on the\nUrinary Output of Gamma-Glutamyl Transpeptidase and of\nN-Acetyl-Beta-D-GIucosaminidase of Male Rats with\nRenovascular Hypertension"],"prefix":"10.1159","author":[{"given":"M.","family":"M\u00e1lyusz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Ehrens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,8,11]]},"container-title":["Enzyme"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000469613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T12:49:56Z","timestamp":1777553396000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000469613","archive":["Portico"],"relation":{},"ISSN":["0013-9432","2504-2564"],"issn-type":[{"value":"0013-9432","type":"print"},{"value":"2504-2564","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,11]]}}}