{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T21:30:44Z","timestamp":1777152644651,"version":"3.51.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"4-5","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurodegener Dis"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> We hypothesize that autoantibodies are induced after the blood-brain barrier is damaged by stroke and the risk of bullous pemphigoid (BP) is increased after stroke. We assess the risk of BP after first-ever stroke in a nationwide population-based cohort of first-ever stroke patients. <b><i>Methods:<\/i><\/b> We extracted data from the Longitudinal Health Insurance Database 2005 and identified patients with first-ever stroke as well as control patients matched for age, gender, and year of enrollment. The risk of BP in first-ever stroke patients in comparison with that in control patients was analyzed using Cox regression. <b><i>Results:<\/i><\/b> Of 12,607 patients with first-ever stroke, 38 (0.3%) patients developed BP in a median of 3.5 years. In the control patients, 8 persons (0.06%) had BP in a median of 3.7 years. The crude hazard ratio (HR) of BP in first-ever stroke patients was 4.83 (95% CI 2.25-10.34, <i>p<\/i> < 0.001) compared to the control group. The adjusted HR was 4.20 (95% CI 1.94-9.08, <i>p<\/i> < 0.001) after adjustments for age, gender, hypertension, diabetes, dementia, epilepsy, Parkinson disease, furosemide, and neuroleptics for stroke patients. <b><i>Conclusions:<\/i><\/b> The risk of BP is increased in first-ever stroke patients in a nationwide population-based cohort and this association is independent of well-known confounders of BP.<\/jats:p>","DOI":"10.1159\/000469710","type":"journal-article","created":{"date-parts":[[2017,5,3]],"date-time":"2017-05-03T21:01:37Z","timestamp":1493845297000},"page":"166-170","source":"Crossref","is-referenced-by-count":7,"title":["Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study"],"prefix":"10.1159","volume":"17","author":[{"given":"Ai-Ling","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu-Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Fu","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Yeh","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4029-9097","authenticated-orcid":false,"given":"Che-Yi","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/00015550410024481"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.596361"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.357"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10386.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000106574"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09122.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.132.3.272"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2014.04.013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.301"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12132"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.07.052"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13285"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.112.1.75"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamadermatol.376"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1991.tb03867.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.02.030"}],"container-title":["Neurodegenerative Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/469710","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/469710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:12:58Z","timestamp":1745428378000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000469710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":16,"journal-issue":{"issue":"4-5","published-online":{"date-parts":[[2017,8,2]]}},"URL":"https:\/\/doi.org\/10.1159\/000469710","archive":["Portico"],"relation":{},"ISSN":["1660-2854","1660-2862"],"issn-type":[{"value":"1660-2854","type":"print"},{"value":"1660-2862","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}