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Since its original description, the characterization, etiological understanding, and therapeutic direction of MID and other VaD subtypes has progressed at an astounding rate. &lt;b&gt;&lt;i&gt;Summary:&lt;\/i&gt;&lt;\/b&gt; This paper divides the landmark discoveries and emergence of new research strategies for MID into decade-defining patterns so that a condensed picture of the total history of MID and its eventual inclusion as a VaD subtype emerges. This paper follows the first descriptive decade, a shift to a preventative focus, a renewed interest coinciding with timely advances in research technology, and a hopeful return to treatment possibilities for VaD. &lt;b&gt;&lt;i&gt;Key Message:&lt;\/i&gt;&lt;\/b&gt; Concisely tracing the historical lineage of the modern understanding of MID, both as a singular entity and as part of the VaD con\u00adstellation of disorders, provides a novel perspective on the foundation upon which future advances in combating vascular contributions to dementia will be based.<\/jats:p>","DOI":"10.1159\/000470836","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T21:03:44Z","timestamp":1493931824000},"page":"160-171","source":"Crossref","is-referenced-by-count":26,"title":["Multi-Infarct Dementia: A Historical 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