{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T02:20:36Z","timestamp":1777342836853,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The study aimed to investigate the association of Crohn's disease (CD) with transcobalamin II (&lt;i&gt;TCN2&lt;\/i&gt;) polymorphisms and serum homocysteine, folate, and vitamin B&lt;sub&gt;12&lt;\/sub&gt; levels. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt;&lt;i&gt;TCN2 &lt;\/i&gt;(rs1801198, rs9606756) were genotyped by iMLDR in 389 CD patients and 746 controls. Furthermore, 102 CD patients and 153 controls were randomly selected for examination of serum homocysteine, folate, and vitamin B&lt;sub&gt;12&lt;\/sub&gt; levels by enzymatic cycling assay and chemiluminescence immunoassay, respectively. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Mutant allele (G) and genotype (AG + GG) of (rs9606756) were higher in CD patients than in controls (both &lt;i&gt;p&lt;\/i&gt; &lt; 0.05). So were they in ileocolonic CD patients and stricturing CD patients compared to controls (all &lt;i&gt;p&lt;\/i&gt; &lt; 0.05). Mutant allele (G) and genotype (CG + GG) of (rs1801198) were more prevalent in stricturing CD patients than in controls (both &lt;i&gt;p&lt;\/i&gt; &lt; 0.05). Compared to controls, average homocysteine level was enhanced in CD patients (&lt;i&gt;p&lt;\/i&gt; = 0.003), whereas average folate and vitamin B&lt;sub&gt;12&lt;\/sub&gt; levels were reduced in CD patients (both &lt;i&gt;p&lt;\/i&gt; &lt; 0.001). The prevalence of hyperhomocysteinemia, folate deficiency, and vitamin B&lt;sub&gt;12&lt;\/sub&gt; deficiency was higher in CD patients than in controls (all &lt;i&gt;p&lt;\/i&gt; &lt; 0.01). Both folate deficiency and vitamin B&lt;sub&gt;12&lt;\/sub&gt; deficiency were independently related to risk of CD (both &lt;i&gt;p&lt;\/i&gt; &lt; 0.01). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt;&lt;i&gt;TCN2 &lt;\/i&gt;(rs1801198, rs9606756) polymorphisms as well as folate deficiency and vitamin B&lt;sub&gt;12&lt;\/sub&gt; deficiency are correlated with CD.<\/jats:p>","DOI":"10.1159\/000471848","type":"journal-article","created":{"date-parts":[[2017,5,4]],"date-time":"2017-05-04T21:02:51Z","timestamp":1493931771000},"page":"463-471","source":"Crossref","is-referenced-by-count":5,"title":["An Analysis of Transcobalamin II Gene Polymorphisms and Serum Levels of Homocysteine, Folate and Vitamin B&lt;sub&gt;12&lt;\/sub&gt; in Chinese Patients with Crohn's Disease"],"prefix":"10.1159","volume":"35","author":[{"given":"Shuzi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanping","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuqing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijia","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,5,5]]},"container-title":["Digestive Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/471848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/471848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:33:14Z","timestamp":1745429594000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000471848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,8,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000471848","archive":["Portico"],"relation":{},"ISSN":["0257-2753","1421-9875"],"issn-type":[{"value":"0257-2753","type":"print"},{"value":"1421-9875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}