{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:31:42Z","timestamp":1761823902073,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Audiol Neurotol"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To identify eventual correlations between the effect of low-pressure treatment and endolymphatic hydrops in M\u00e9ni\u00e8re patients. &lt;b&gt;&lt;i&gt;Material and Methods:&lt;\/i&gt;&lt;\/b&gt; The study group consisted of subjects affected by definite M\u00e9ni\u00e8re disease (2015) and a severe degree of disability, who received a ventilation tube with or without a low-pressure treatment before undergoing a surgical procedure (vestibular neurectomy). After the placement of the ventilation tube, the subjects were either left alone with the tube or received 1 month of self-administered low-pressure therapy with a portable device. In all subjects, an electrocochleography (ECochG) was performed and specific questionnaires - Dizziness Handicap Inventory (DHI) and Functional Scale Level (FSL) - were completed before starting either arm of treatment, at the end of treatment, and then 3 and 6 months later. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; All selected subjects presented with an ECochG pattern that was indicative of endolymphatic hydrops before starting either treatment. At the end of pressure treatment, 80% showed symptomatic improvement while maintaining the hydropic ECochG pattern. At the 3-month control stage, the hydropic pattern resulted normalized (&lt;0.5) in all the improved subjects. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Although 1 month of low-pressure treatment provided a positive symptomatological outcome, normalization of the hydropic ECochG parameters occurred only at a later time. Therefore, it is possible to assume that endolymphatic hydrops could be concurrent with a non-symptomatic stage of M\u00e9ni\u00e8re disease, and that the anti-hydropic effect of the low-pressure treatment, if any, would present with a certain delay after its completion.<\/jats:p>","DOI":"10.1159\/000472245","type":"journal-article","created":{"date-parts":[[2017,5,17]],"date-time":"2017-05-17T21:01:36Z","timestamp":1495054896000},"page":"24-29","source":"Crossref","is-referenced-by-count":8,"title":["Delayed Effect of Active Pressure Treatment on Endolymphatic Hydrops"],"prefix":"10.1159","volume":"22","author":[{"given":"Edoardo","family":"Covelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Volpini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Atturo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Teresa","family":"Benincasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Tarentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vania","family":"Marrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Monini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annarita","family":"Vestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Barbara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,5,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701200319"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3109\/00016488609119424"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3109\/00016489709124015"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/00206097709071852"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215112000102"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510008960X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1990.01870040046011"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000001144"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70100-1"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000276016"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/000348947808700601"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200501000-00012"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3109\/00016487709128803"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008419.pub2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25576"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000957"}],"container-title":["Audiology and Neurotology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/472245","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/472245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T17:34:08Z","timestamp":1745429648000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000472245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,7,28]]},"published-print":{"date-parts":[[2017,8,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000472245","archive":["Portico"],"relation":{},"ISSN":["1420-3030","1421-9700"],"issn-type":[{"type":"print","value":"1420-3030"},{"type":"electronic","value":"1421-9700"}],"subject":[],"published":{"date-parts":[[2017]]}}}