{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:22:35Z","timestamp":1779236555905,"version":"3.51.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> We reviewed patients with fever of unknown origin (FUO) and splenomegaly and assessed the diagnostic value of splenectomy and measured risk factors suggestive of an underlying lymphoma. <b><i>Methods:<\/i><\/b> FUO patients (<i>n<\/i> = 83) who had splenomegaly and underwent splenectomy were enrolled into this retrospective single-center study. Clinical presentations were documented and risk factors suggestive of an underlying lymphoma were tested. <b><i>Results:<\/i><\/b> Seventy-four patients (89.2%) had a diagnosis of lymphoma or not after splenectomy and follow-up. Of those (55.4%) diagnosed with lymphoma, 29 had B-cell non-Hodgkin lymphoma and 12 had T-cell non-Hodgkin lymphoma. The remaining 33 (44.6%) had diseases other than lymphoma. Using multivariate logistic analysis, the following 3 independent risk factors were found to be related to a final diagnosis of lymphoma: age (continuous) (HR 1.086; 95% CI 1.033-1.141; <i>p<\/i> = 0.001), massively enlarged spleen (HR 7.797; 95% CI 1.267-47.959; <i>p<\/i> = 0.027), and enlarged intra-abdominal lymph nodes (HR 63.925; 95% CI 7.962-513.219; <i>p<\/i> < 0.001). The calibration of the model was satisfactory (<i>p<\/i> = 0.248 using the Hosmer-Lemeshow test), and the discrimination power was good (area under the receiver operating characteristic curve 0.925; 95% CI 0.863-0.987). <b><i>Conclusions:<\/i><\/b> Splenectomy is an effective diagnostic procedure for patients with FUO and splenomegaly and lymphoma is a common cause. Older age, a massively enlarged spleen, and enlarged intra-abdominal lymph nodes are risk factors suggesting an underlying lymphoma, and surgery for high-risk patients should be considered.<\/jats:p>","DOI":"10.1159\/000473859","type":"journal-article","created":{"date-parts":[[2017,6,6]],"date-time":"2017-06-06T21:01:37Z","timestamp":1496782897000},"page":"240-246","source":"Crossref","is-referenced-by-count":4,"title":["Patients with Fever of Unknown Origin and Splenomegaly: Diagnostic Value of Splenectomy and Preoperative Risk Factors Suggestive of Underlying Lymphomas"],"prefix":"10.1159","volume":"137","author":[{"given":"Lu","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huacong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tienan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minghui","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shujie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daobin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1068308"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31802fe858"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000118632"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-6-199903160-00002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/00365540600606564"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25765"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1993.tb07301.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00550-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473859","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473859","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:18:31Z","timestamp":1745425111000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000473859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,6,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000473859","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}