{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T11:30:03Z","timestamp":1748431803378,"version":"3.40.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> In infants with left-sided obstructive lesions (LSOL), the presence of retrograde blood flow in either the ascending or descending aorta may lead to diminished cerebral and renal blood flow, respectively. <b><i>Objectives:<\/i><\/b> Our aim was to compare cerebral and renal tissue oxygen saturation (rSO<sub>2<\/sub>) between infants with LSOL with antegrade and retrograde blood flow in the ascending aorta and with and without diastolic backflow in the descending aorta. <b><i>Methods:<\/i><\/b> Based on 2 echocardiograms, the study group was categorized according to the direction of blood flow in the ascending and descending aorta. We measured cerebral and renal rSO<sub>2<\/sub> using near-infrared spectroscopy and calculated fractional tissue oxygen extraction (FTOE). <b><i>Results:<\/i><\/b> Nineteen infants with LSOL, admitted to the NICU between 0 and 28 days after birth, were included. Infants with antegrade blood flow (<i>n <\/i>= 12) and infants with retrograde blood flow in the ascending aorta (<i>n<\/i> = 7) had similar cerebral rSO<sub>2<\/sub> and FTOE during both echocardiograms. Only during the first echocardiogram, infants with retrograde blood flow in the ascending aorta had lower renal FTOE (0.14 vs. 0.32,<i> p<\/i> = 0.04) and tended to have higher renal rSO<sub>2<\/sub> (80 vs. 65%,<i> p<\/i> = 0.09). The presence of diastolic backflow in the descending aorta was not associated with cerebral or renal rSO<sub>2<\/sub> and FTOE during the first (<i>n<\/i> = 8) as well as the second echocardiogram (<i>n<\/i> = 10). <b><i>Conclusions:<\/i><\/b> Retrograde blood flow in the ascending aorta was not associated with cerebral oxygenation, while diastolic backflow in the descending aorta was not associated with renal oxygenation in infants with LSOL.<\/jats:p>","DOI":"10.1159\/000473870","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T21:01:29Z","timestamp":1499979689000},"page":"217-224","source":"Crossref","is-referenced-by-count":3,"title":["Cerebral and Renal Oxygen Saturation Are Not Compromised in the Presence of Retrograde Blood Flow in either the Ascending or Descending Aorta in Term or Near-Term Infants with Left-Sided Obstructive Lesions"],"prefix":"10.1159","volume":"112","author":[{"given":"Michelle E.","family":"van der Laan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9037-8653","authenticated-orcid":false,"given":"Mirthe J.","family":"Mebius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus T.R.","family":"Roofthooft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arend F.","family":"Bos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf M.F.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth M.W.","family":"Kooi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e318265ee8a"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951105002398"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/359390"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2007.12.013"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067393"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2010.06.011"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e32834aa583"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.547961"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/uog.1785"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.106.5.1080"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2007.09.036"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e31815b4830"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-2640"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(96)80107-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.05.003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000101063"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2010.02.110"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1349894"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-200203000-00011"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.133"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2015.08.004"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473870","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:18:40Z","timestamp":1745425120000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000473870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,10,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000473870","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5203798","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2017]]}}}