{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:04:03Z","timestamp":1792101843226,"version":"4.4.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Rep Dermatol"],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is a challenging skin disease with limited therapeutic options. Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. A combination of metformin, liraglutide, levonorgestrel-ethinyl estradiol, dapsone, and finasteride was initiated. Acute antibiotic use for recurrences and flares could be slowly discontinued. Over the course of 3 years on this regimen, the liver enzymes normalized in 1 year, followed in2 years by complete resolution of the majority of the hematological and metabolic abnormalities. The sedimentation rate reduced from over 120 to 34 mm\/h. She required 1 surgical intervention for perianal disease after 9 months on the regimen. Flares greatly diminished in intensity and duration, with none in the past 6 months. Right axillary lesions have completely healed with residual disease greatly reduced. Chiefly abdominal lesions are persistent. She was able to complete high school from home, start a job, and resume a normal life. Initial weight loss of 40 pounds was not maintained. The current regimen is being well tolerated and continued.<\/jats:p>","DOI":"10.1159\/000473873","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T21:01:30Z","timestamp":1499979690000},"page":"70-78","source":"Crossref","is-referenced-by-count":31,"title":["A Disease-Modifying Approach for Advanced Hidradenitis Suppurativa (Regimen with Metformin, Liraglutide, Dapsone, and Finasteride): A Case Report"],"prefix":"10.1159","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3101-6406","authenticated-orcid":false,"given":"Birgit\u00a0N.","family":"Khandalavala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1014163"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000329023"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/09546630600830588"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080\/09546630510031403"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.2874"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031810"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.014"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.255"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.rchipe.2015.10.001"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.055"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.001"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13090"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1800"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.11.014"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.472"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031810"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09198.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04668.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1409-7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.06.020"}],"container-title":["Case Reports in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473873","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473873","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:18:43Z","timestamp":1745425123000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000473873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,13]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,12,12]]}},"URL":"https:\/\/doi.org\/10.1159\/000473873","archive":["Portico"],"relation":{},"ISSN":["1662-6567"],"issn-type":[{"value":"1662-6567","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,13]]}}}