{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:26:38Z","timestamp":1783571198206,"version":"3.55.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T00:00:00Z","timestamp":1491350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2018]]},"abstract":"<b><i>Objectives:<\/i><\/b> Neurokinin B (NKB) and kisspeptin are obligate for normal gonadotropin secretion, and links between gonadotropin-releasing hormone (GnRH) pulsatility and vasomotor symptoms have been proposed. Using a selective NKB receptor (NK3R) antagonist, the role of NKB in the hypergonadotropic state in menopausal women was explored. <b><i>Methods:<\/i><\/b> Eleven postmenopausal women were administered the NK3R antagonist MLE4901 at 40 mg twice daily orally for 7 days. Ten-minute blood sampling for 8 h was performed before and on the last day of NK3R antagonist treatment for luteinising hormone (LH) pulsatility analysis with kisspeptin-10 (0.3 \u00b5g\/kg i.v. bolus) administered at 6 h on both days. Hot flash frequency and severity were self-reported for 7 days before and during NK3R antagonist administration. <b><i>Results:<\/i><\/b> LH fell from 29.3 \u00b1 4.1 to 24.4 \u00b1 3.8 IU\/L (<i>p<\/i> < 0.05) after 7 days of NK3R antagonist treatment, with no change in follicle-stimulating hormone (FSH). Basal (non-pulsatile) LH secretion was reduced (549.0 \u00b1 70.8 vs. 366.1 \u00b1 92.1 IU\/L\/6 h, <i>p<\/i> = 0.006), and while the LH pulse frequency did not change in the group as a whole (from 0.8 \u00b1 0.1 to 0.7 \u00b1 0.1 pulses\/h, ns), it did fall in the 8 women with hot flashes (from 1.0 \u00b1 0.1 to 0.7 \u00b1 0.1 pulses\/h, <i>p<\/i> < 0.05). These women also reported a reduction in hot flash frequency (from 3.4 \u00b1 1.2 to 1.0 \u00b1 0.6 hot flashes\/day, <i>p<\/i> = 0.008) whilst taking the NK3R antagonist. Kisspeptin-10 did not affect LH secretion with or without the NK3R antagonist. <b><i>Conclusions:<\/i><\/b> The administration of an NK3R antagonist indicates a role for NKB in the regulation of LH\/GnRH in postmenopausal women, whereas the lack of response to kisspeptin may reflect the hypo-oestrogenic state. These data support a link of LH\/GnRH pulsatility and vasomotor symptoms with NK3R antagonism as a potential therapeutic approach.<\/jats:p>","DOI":"10.1159\/000473893","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T21:04:01Z","timestamp":1491426241000},"page":"148-157","source":"Crossref","is-referenced-by-count":69,"title":["Neurokinin 3 Receptor Antagonism Reveals Roles for Neurokinin B in the Regulation of Gonadotropin Secretion and Hot Flashes in Postmenopausal Women"],"prefix":"10.1159","volume":"106","author":[{"given":"Karolina","family":"Skorupskaite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothis T.","family":"George","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes D.","family":"Veldhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Millar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,4,5]]},"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473893","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473893","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/473893","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:19:01Z","timestamp":1745425141000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000473893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,5]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,22]]},"published-print":{"date-parts":[[2018,2,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000473893","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,5]]}}}