{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T19:36:15Z","timestamp":1778700975497,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Visc Med"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to analyze the admissions and the management of peptic ulcer disease (PUD) in a tertiary care surgical center. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We evaluated the medical records of all patients admitted to the University Hospital of T\u00fcbingen, Germany, for treatment of PUD during 1989-2008. Patients were included into the study if the diagnosis was verified endoscopically or surgically. Annual number of admissions, length of hospitalization, mortality rate, age, rate of non-steroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitor (PPI) medication, rate of &lt;i&gt;Helicobacter pylori&lt;\/i&gt; infection, and complications of PUD and surgery performed were recorded. Data were analyzed by descriptive analyses, Pearson's chi-square test, and regression analysis. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; This study included 614 admissions. The number of annual admissions (31 \u00b1 12), the length of hospitalization (9 \u00b1 3 days), and the mortality rate (5 \u00b1 4% per year) remained constant, whereas the age increased (1989: 52 \u00b1 14 years vs. 2008: 67 \u00b1 16 years). The rates of patients with &lt;i&gt;H. pylori&lt;\/i&gt; infection (47 \u00b1 28% per year), NSAIDs treatment (29 \u00b1 15% per year), and PPI treatment (31 \u00b1 27% per year) remained constant. The most frequent PUD complication was hemorrhage (42 \u00b1 16% per year), followed by perforation (9 \u00b1 8% per year). During 1999-2008, more hemorrhages (125 vs. 121; p &lt; 0.05) and perforations (40 vs. 21; p &lt; 0.05) were registered than during 1989-1998. The rate of emergency surgery increased from 70% during 1989-1998 to 87% during 1999-2008. In contrast, elective surgery decreased from 21% during 1989-1998 to 7% during 1999-2008. Ulcer excision and oversewing was the most frequent surgical procedure performed (59%), with decreasing rates of acid-reducing surgery. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Despite recent advances in PUD management, ulcer hemorrhage and perforation remain a significant health burden and a surgical disease.<\/jats:p>","DOI":"10.1159\/000475450","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T21:06:57Z","timestamp":1497560817000},"page":"221-226","source":"Crossref","is-referenced-by-count":20,"title":["Gastric Ulcer Complications after the Introduction of Proton Pump Inhibitors into Clinical Routine: 20-Year Experience"],"prefix":"10.1159","volume":"33","author":[{"given":"Friederike","family":"Eisner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khaled","family":"Bajaeifer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Glatzle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"K\u00f6nigsrainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus A.","family":"K\u00fcper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,6,16]]},"container-title":["Visceral Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/475450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/475450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:20:11Z","timestamp":1745425211000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000475450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,6,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000475450","archive":["Portico"],"relation":{},"ISSN":["2297-4725","2297-475X"],"issn-type":[{"value":"2297-4725","type":"print"},{"value":"2297-475X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}