{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:30:51Z","timestamp":1766269851537,"version":"3.40.5"},"reference-count":30,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ocul Oncol Pathol"],"published-print":{"date-parts":[[2018]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Hemophagocytic lymphohistiocytosis (HLH) is an infrequent inflammatory multisystemic syndrome. Only rare cases with ophthalmic involvement describing their pathologic features have been previously reported. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We report 3 cases of adult-onset HLH with bilateral ocular involvement and describe their clinicopathologic features. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Three adult males - 2 with a history of viral infection - developed persistent fever, fatigue, bone marrow abnormalities, and irreversible multiorgan failure. Visual impairment was also documented in 2 cases. Complete autopsies were performed. Ophthalmic pathology demonstrated a bilateral histiocytic infiltrate with scant lymphocytes affecting the uvea. Focal extension to the retina, optic nerve, and trabecular meshwork were also identified, as well as hemophagocytosis in 1 case. Macrophages showed strong immunoreactivity for CD163 antibody and lacked BRAF p.V600E mutant protein. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; HLH is an unusual disorder associated with several systemic conditions. Histologic features in the eye are poorly documented, with prior reports restricted to children. Our 3 adult cases are reported using updated criteria and, despite the difference in age, show changes similar to those observed in the pediatric population.<\/jats:p>","DOI":"10.1159\/000475551","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T21:09:09Z","timestamp":1496264949000},"page":"1-11","source":"Crossref","is-referenced-by-count":13,"title":["Hemophagocytic Lymphohistiocytosis in Adults with Intraocular Involvement: Clinicopathologic Features of 3 Cases"],"prefix":"10.1159","volume":"4","author":[{"given":"M. Adelita","family":"Vizcaino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2910-9427","authenticated-orcid":false,"given":"Charles G.","family":"Eberhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto J.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s12098-016-2037-y"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2016.05.022"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-408864"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13064"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.02.050"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.05.001"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2016(04)05"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-690636"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-012-1765-x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1177\/2324709616647409"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0772-8"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3201\/eid2206.151682"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-10-678862"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30084"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26033"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/08880019809014022"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)70802-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1991.01080060033015"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000000255"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.124.11.1656"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2012.665123"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000000064"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2015.1107593"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1177\/0883073811435237"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1968.03850040415009"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(81)90007-6"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/BF00946941"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-05-430140"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-015-3094-z"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1997.49"}],"container-title":["Ocular Oncology and Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/475551","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/475551","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:21:05Z","timestamp":1745425265000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000475551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,1]]},"references-count":30,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,12,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000475551","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5057470","asserted-by":"subject"}]},"ISSN":["2296-4681","2296-4657"],"issn-type":[{"type":"print","value":"2296-4681"},{"type":"electronic","value":"2296-4657"}],"subject":[],"published":{"date-parts":[[2017,6,1]]}}}