{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:04:15Z","timestamp":1791241455698,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; Approximately 20-40% of patients with gastroesophageal reflux disease (GERD) are refractory to proton pump inhibitor (PPI) treatment. The acid-inhibitory effect of vonoprazan, a novel potassium-competitive acid blocker (P-CAB), is significantly greater when compared to the effect of PPIs. We investigated the efficacy of vonoprazan treatment for PPI-refractory GERD and factors associated with P-CAB non-response. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We enrolled 277 GERD patients receiving continuous PPI therapy. Subjects completed a self-report questionnaire including the frequency scale for the symptoms of GERD (FSSG). Patients with PPI-refractory GERD received 20 mg of vonoprazan once daily for 8 weeks. After that, subjects completed the same questionnaire, and the results were used to identify P-CAB responders and non-responders. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Twenty-eight patients were identified as P-CAB responders and 26 were non-responders. Vonoprazan treatment significantly decreased scores of FSSG, nighttime symptom, and Athens Insomnia Scale. Multivariate analysis demonstrated co-existing functional dyspepsia (FD; OR 4.94) and the presence of sleep disturbances (OR 4.34) was associated with P-CAB non-response, whereas alcohol consumption was inversely associated. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Vonoprazan treatment might be appropriate as a promising new strategy for PPI-refractory GERD. Co-existing FD, sleep disturbances, and alcohol abstinence were significantly associated with P-CAB non-response. Other therapeutic options should be considered in patients with these factors.<\/jats:p>","DOI":"10.1159\/000475658","type":"journal-article","created":{"date-parts":[[2017,5,12]],"date-time":"2017-05-12T21:02:25Z","timestamp":1494622945000},"page":"281-287","source":"Crossref","is-referenced-by-count":31,"title":["Factors Associated with Potassium-Competitive Acid Blocker Non-Response in Patients with Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease"],"prefix":"10.1159","volume":"95","author":[{"given":"Masatsugu","family":"Okuyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Nakahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narika","family":"Iwakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Hasegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maizumi","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Ishizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02531.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.05.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13331"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1227-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-004-1417-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2016.1224383"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3999(00)00095-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1983.tb09716.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9270(03)00009-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07074.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04583.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000354071"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.221_a.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13325"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2960-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41210.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300798"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.09.039"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0601-4"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2013.19.1.61"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313312"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/475658","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/475658","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:22:12Z","timestamp":1745425332000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000475658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":22,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,7,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000475658","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}