{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:45:13Z","timestamp":1792028713296,"version":"4.4.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> Vitamin D deficiency is a global public health problem. The published literature on vitamin D deficiency is limited among Arab pregnant women and its association with different metabolic markers. <b><i>Objective:<\/i><\/b> To determine the prevalence of vitamin D deficiency in Arab pregnant women and neonates and its association with various biomarker profiles. <b><i>Methods:<\/i><\/b> This is a multicenter study taken from a large prospective project in Riyadh, the capital city of Saudi Arabia. Maternal biochemical levels were measured routinely. Maternal and neonatal 25(OH)D levels were assessed using a chemiluminescence immunoassay. A total of 1,097 pregnant women >16 years old with gestational ages <24 weeks were recruited from different tertiary hospitals in Riyadh between February 2011 and June 2012. <b><i>Results:<\/i><\/b> Almost 85% of pregnant subjects had 25(OH)D level <50 nmol\/L. Vitamin D deficiency among neonates was 88%. Maternal 25(OH)D was significantly associated with neonatal 25(OH)D (<i>r<\/i> = 0.54, <i>p<\/i> < 0.01), as well as serum calcium (<i>r<\/i> = 0.16, <i>p<\/i> = 0.02) and phosphate levels (<i>r<\/i> = 0.17, <i>p<\/i> = 0.02), and had an inverse correlation with parathyroid hormone (<i>r<\/i> = -0.22, <i>p<\/i> = 0.001). <b><i>Conclusion:<\/i><\/b> Maternal and neonatal vitamin D deficiency is alarmingly high in Arabs and significantly associated with each another. Universal screening for serum 25(OH)D may be appropriate for Arab mothers and vitamin D supplementation mandatory until term. The study puts a spotlight on vitamin D deficiency with the hope that health professionals will address it adequately to prevent the known long-term consequences for metabolism and bone health of both mothers and their children.<\/jats:p>","DOI":"10.1159\/000475704","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T17:01:29Z","timestamp":1499965289000},"page":"225-230","source":"Crossref","is-referenced-by-count":21,"title":["Extremely High Prevalence of Maternal and Neonatal Vitamin D Deficiency in the Arab Population"],"prefix":"10.1159","volume":"112","author":[{"given":"Mona A.","family":"Fouda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iqbal Z.","family":"Turkestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Almusharraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrahman","family":"Al-Ajlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima F.","family":"Angkaya-Bagayawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Sabico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashry Gad","family":"Mohammed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Hassanato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Al-Serehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naemah M.","family":"Alshingetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasser M.","family":"Al-Daghri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.11.003"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2016.12.017"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/917428"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-016-0295-y"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra070553"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-014-1499-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f1169"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.03.058"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2012.01283.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)67922-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0279"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900652"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1639-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-016-0901-4"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198408000-00013"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1391"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2008.00157.x"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/475704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/475704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:22:35Z","timestamp":1745410955000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000475704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,10,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000475704","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}