{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:26:32Z","timestamp":1774351592838,"version":"3.50.1"},"reference-count":28,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Background:<\/i><\/b> This analysis compared efficacy, renal function, and histology in kidney transplant recipients receiving tacrolimus (TAC) combined with everolimus (EVR) or mycophenolate (MPS). <b><i>Methods:<\/i><\/b> This was a retrospective analysis from a randomized trial in kidney transplant recipients who received a single 3 mg\/kg dose of rabbit antithymocyte globulin (r-ATG), TAC, EVR, and prednisone (PRED; r-ATG\/EVR, <i>n<\/i> = 85), basiliximab (BAS), TAC, EVR, and PRED (BAS\/EVR, <i>n<\/i> = 102) or BAS, TAC, MPS, and PRED (BAS\/MPS, <i>n<\/i> = 101). We evaluated the incidence of de novo donor-specific anti-human leukocyte antigens antibodies (DSA) and histology on protocol biopsies at 12 months, and the incidence of acute rejection, estimated glomerular filtration rate (eGFR) and proteinuria at 36 months. <b><i>Results:<\/i><\/b> At 12 months, there were no differences in de novo DSA (6.4 vs. 3.4 vs. 5.5%) or in subclinical inflammation (2.0 vs. 4.8 vs. 10.2%), interstitial fibrosis\/tubular atrophy (57.1 vs. 58.5 vs. 53.8%) and C4d deposition (2.0 vs. 7.3 vs. 2.6%). At 36 months, there were no differences in the incidence of treatment failure (19.0 vs. 27.7 vs. 27.7%, <i>p<\/i> = 0.186), first biopsy-proven acute rejection (9.5 vs. 21.8 vs. 16.8%, <i>p<\/i> = 0.073), and urine protein\/creatinine ratios (0.53 \u00b1 1.05 vs. 0.62 \u00b1 0.75 vs. 0.71 \u00b1 1.24). eGFR was lower in the BAS\/EVR compared to that in the BAS\/MPS group (53.4 \u00b1 20.9 vs. 50.8 \u00b1 19.5 vs. 60.7 \u00b1 21.2 mL\/min\/1.73 m<sup>2<\/sup>, <i>p<\/i> = 0.017) but comparable using a sensitive analysis (49.5 \u00b1 23 vs. 47.5 \u00b1 22.6 vs. 53.6 \u00b1 27.8 mL\/min\/1.73 m<sup>2<\/sup>, <i>p<\/i> = 0.207). <b><i>Conclusion:<\/i><\/b> In this cohort, the use of EVR and reduced TAC concentrations were associated with comparable efficacy, renal function, and histological parameters compared to the standard-of-care immunosuppressive regimen.<\/jats:p>","DOI":"10.1159\/000475888","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T21:01:53Z","timestamp":1494968513000},"page":"497-508","source":"Crossref","is-referenced-by-count":18,"title":["Donor-Specific Anti-Human Leukocyte Antigens Antibodies, Acute Rejection, Renal Function, and Histology in Kidney Transplant Recipients Receiving Tacrolimus and Everolimus"],"prefix":"10.1159","volume":"45","author":[{"given":"Alexandra","family":"Ferreira","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Felipe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Cristelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Viana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geovana","family":"Basso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suelen","family":"Stopa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Mansur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayara","family":"Ivani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrieli","family":"Bessa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila","family":"Ruppel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilson","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gerbase-DeLima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique","family":"Proen\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helio","family":"Tedesco-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Medina-Pestana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067411"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02726.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl134"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2010.03129.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182848e03"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318166927b"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01465.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13327"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.077180"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14090"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14215"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181a23cb2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000219703.39149.85"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318279153c"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00015.2012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2147\/OAJCT.S63058"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04334.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318224c12d"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62318-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12481"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020009"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03961.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014040378"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000748"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14186"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03637.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12656"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001244"}],"container-title":["American 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