{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:15:37Z","timestamp":1781889337826,"version":"3.54.5"},"reference-count":84,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2017]]},"abstract":"<jats:p>Chronic inflammation and angiogenesis are the most common complications in patients undergoing maintenance peritoneal dialysis (PD), resulting in progressive peritoneum remolding and, eventually, utrafiltration failure. Contributing to the deeper tissue under the peritoneal membrane, adipocytes play a neglected role in this process. Some adipokines act as inflammatory and angiogenic promoters, while others have the opposite effects. Adipokines, together with inflammatory factors and other cytokines, modulate inflammation and neovascularization in a coordinated fashion. This review will also emphasize cellular regulators and their crosstalk in long-term PD. Understanding the molecular mechanism, targeting changes in adipocytes and regulating adipokine secretion will help extend therapeutic methods for preventing inflammation and angiogenesis in PD.<\/jats:p>","DOI":"10.1159\/000476017","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T21:01:36Z","timestamp":1494018096000},"page":"209-219","source":"Crossref","is-referenced-by-count":21,"title":["Angiogenesis and Inflammation in Peritoneal Dialysis: The Role of Adipocytes"],"prefix":"10.1159","volume":"42","author":[{"given":"Jun","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manshu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixiao","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2017,5,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.100"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.11.015"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000450563"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011060607"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2015.00204"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2013.99"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003717"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000326953"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp384"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10047-013-0702-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp479"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002040"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2005.08.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1797.2011.01502.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.02629.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft256"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060776"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2015.1127741"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3543678"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr370"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002016"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.02.027"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2010.01000.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-014-9444-3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9402-5"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.09.183"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.5301\/ijao.5000123"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1227"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.6.7.4328"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.8.1480"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/nep.12746"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901511"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.306"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2009.17"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2015.1056409"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.6.3369"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2014.02.011"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111430998"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802139200"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2016.01.018"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28927"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2012.166"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.4310"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.08.097"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.3747\/pdi.2009.00131"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02320311"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.krcp.2015.12.007"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.5049\/EBP.2015.13.1.22"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.615968"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2010.05460.x"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr244"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.217"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120690"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2006.00119.x"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018823"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr774"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-9987.2010.00847.x"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000409"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14059751"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.307"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1159\/000314544"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1159\/000443442"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2013.12.003"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.29865"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.262"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2006.317"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0741-4"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2007.08.002"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.01.026"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.454835"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2013.04.005"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1038\/nature10426"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.5551\/jat.3939"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2015.1041582"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04260.x"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2196"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-013-9381-6"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20341"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1770"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.07.031"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M500294-JLR200"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-663245"},{"key":"ref83","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv147"},{"key":"ref84","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00240.2015"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/476017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/476017","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/476017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:25:29Z","timestamp":1745425529000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000476017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":84,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,6,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000476017","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}