{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:33:01Z","timestamp":1758126781205,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2017]]},"abstract":"<b><i>Introduction:<\/i><\/b> The finding of a raised intraepithelial lymphocytes (IELs) count with normal villous architecture is of sufficient clinical importance to be reported in routine duodenal biopsies. <b><i>Aim:<\/i><\/b> To study the clinical and demographic data of patients with isolated increased IELs on duodenal biopsy. <b><i>Methods:<\/i><\/b> A single-tertiary-centre retrospective study was carried out with a review of medical records of patients with increased IELs. Patients from 2012 to 2014, >18 years with at least one biopsy from the second part of the duodenum with increased IELs; defined as >25 IELs\/100 enterocytes, with preserved villous architecture were identified from our histopathology database with exclusion of patients with coeliac disease (CD).Clinical and demographic data were recorded following a chart review. CD was diagnosed by the attending physician based on the Physician Global Assessment. Data was compared between groups using a Student <i>t<\/i> test and ORs were calculated as appropriate. Statistical significance was set a priori at <i>p<\/i> < 0.05. <b><i>Results:<\/i><\/b> Over 24 months, 6,244 patients were found to have duodenal biopsies and 114 (1.8%) had isolated increased IELs. Of the patients with increased IELs, the mean age was 50 years and 34 (30%) were male. Follow-up was available in 75 (65%) of these and CD was subsequently diagnosed in 32% (<i>n<\/i> = 24). CD was associated with the female gender (22 out of 24 vs. 39 out of 51, OR 7.5, older age 55 vs. 41 years, <i>p<\/i> < 0.04), and higher IEL count with an IEL of >40 in 11 out of 24 (46%) with CD vs. 12 out of 51 (24%) without CD, <i>p<\/i> = 0.0006. <b><i>Conclusion:<\/i><\/b> It is a non-specific but important finding, as it can have clinical implications.<\/jats:p>","DOI":"10.1159\/000476061","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T21:01:21Z","timestamp":1494968481000},"page":"288-292","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Outcome of Patients with Raised Intraepithelial Lymphocytes with Normal Villous Architecture on Duodenal Biopsy"],"prefix":"10.1159","volume":"95","author":[{"given":"Vikrant","family":"Parihar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roisin","family":"Stack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Alakkari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nial","family":"Breslin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.M.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Crowther","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deidre","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2017,5,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.22.012703.104522"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.5.393"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310007675"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010729207320"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07631.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/gut.15.5.387"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800404"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200104000-00010"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.01.008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.11.040"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03609.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/2050640615573374"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04477.x"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/476061","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/476061","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T16:25:48Z","timestamp":1745425548000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000476061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2017,7,4]]}},"URL":"https:\/\/doi.org\/10.1159\/000476061","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2017]]}}}